Ruthenium-catalyzed oxidative coupling of 2-aryl-4-quinazolinones with olefins: synthesis of pyrrolo[2,1-b]quinazolin-9(1H)-one motifs

Ruthenium-catalyzed oxidative coupling of 2-aryl-4-quinazolinones with olefins: synthesis of pyrrolo[2,1-b]quinazolin-9(1H)-one motifs

A ruthenium-catalyzed oxidative coupling of 2-aryl-quinazolinones with olefins via C-H bond activation followed by an intramolecular aza-Michael reaction is described. This strategy allows the direct and efficient construction of pyrrolo[2,1-b]quinazolin-9(1H)-one scaffolds.

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Veröffentlicht in:Organic & biomolecular chemistry 2015-06, Vol.13 (23), p.6474-6478
Hauptverfasser: Zheng, Yong, Song, Wei-Bin, Zhang, Shu-Wei, Xuan, Li-Jiang
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes - chemistry
Catalysis
Chemistry Techniques, Synthetic
Oxidative Coupling
Quinazolinones - chemical synthesis
Quinazolinones - chemistry
Ruthenium - chemistry
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Zusammenfassung:A ruthenium-catalyzed oxidative coupling of 2-aryl-quinazolinones with olefins via C-H bond activation followed by an intramolecular aza-Michael reaction is described. This strategy allows the direct and efficient construction of pyrrolo[2,1-b]quinazolin-9(1H)-one scaffolds.
ISSN:1477-0520
1477-0539
DOI:10.1039/c5ob00601e