Facilitation of cocaine kindling by glucocorticoids in rats

We report that glucocorticoids significantly facilitated the development of cocaine-induced kindled seizures. These results suggest that glucocorticoids may have effects on the development of kindled seizures which are similar to those of the neuropeptide, corticotropin-releasing hormone (CRH), with...

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Veröffentlicht in:	Brain research 1993-11, Vol.629 (1), p.163-166
Hauptverfasser:	Kling, Mitchel A., Smith, Mark A., Glowa, John R., Pluznik, Daniel, Demas, Jay, DeBellis, Michael D., Gold, Philip W., Schulkin, Jay
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cocaine Cocaine - toxicity Corticosterone - toxicity Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dexamethasone Dexamethasone - toxicity Drug Synergism Glucocorticoid Kindling Kindling, Neurologic - drug effects Male Medical sciences Motor Activity - drug effects Neurology Rats Rats, Sprague-Dawley Seizures - chemically induced Seizures - physiopathology Sensitization Stereotyped Behavior - drug effects
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Zusammenfassung:	We report that glucocorticoids significantly facilitated the development of cocaine-induced kindled seizures. These results suggest that glucocorticoids may have effects on the development of kindled seizures which are similar to those of the neuropeptide, corticotropin-releasing hormone (CRH), with which they show a close functional relationship. These results may be of interest in the light of data showing that glucocorticoids increase CRH expression in the central nucleus of the amygdala, which is an important site for the development of kindling.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(93)90497-B