Esterase- and pH-responsive poly(β-amino ester)-capped mesoporous silica nanoparticles for drug delivery

Gating of mesoporous silica nanoparticles (MSNs) with the stimuli-responsive poly(β-amino ester) has been achieved. This hybrid nanocarrier releases doxorubicin (DOX) under acidic conditions or in the presence of porcine liver esterase. The DOX loaded poly(β-amino ester)-capped MSNs reduce cell viab...

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Veröffentlicht in:	Nanoscale 2015-04, Vol.7 (16), p.7178-7183
Hauptverfasser:	Fernando, Isurika R, Ferris, Daniel P, Frasconi, Marco, Malin, Dmitry, Strekalova, Elena, Yilmaz, M Deniz, Ambrogio, Michael W, Algaradah, Mohammed M, Hong, Michael P, Chen, Xinqi, Nassar, Majed S, Botros, Youssry Y, Cryns, Vincent L, Stoddart, J Fraser
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - toxicity Cell Line, Tumor Cell Survival - drug effects Doxorubicin - chemistry Doxorubicin - toxicity Drug Carriers - chemistry Drug delivery systems Esterases - chemistry Esterases - metabolism Esters Gating and risering Human Humans Hydrogen-Ion Concentration Liver Nanoparticles Nanoparticles - chemistry Nanostructure Polymers - chemistry Porosity Silicon dioxide Silicon Dioxide - chemistry Swine
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