Esterase- and pH-responsive poly(β-amino ester)-capped mesoporous silica nanoparticles for drug delivery

Esterase- and pH-responsive poly(β-amino ester)-capped mesoporous silica nanoparticles for drug delivery

Gating of mesoporous silica nanoparticles (MSNs) with the stimuli-responsive poly(β-amino ester) has been achieved. This hybrid nanocarrier releases doxorubicin (DOX) under acidic conditions or in the presence of porcine liver esterase. The DOX loaded poly(β-amino ester)-capped MSNs reduce cell viab...

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Veröffentlicht in:Nanoscale 2015-04, Vol.7 (16), p.7178-7183
Hauptverfasser: Fernando, Isurika R, Ferris, Daniel P, Frasconi, Marco, Malin, Dmitry, Strekalova, Elena, Yilmaz, M Deniz, Ambrogio, Michael W, Algaradah, Mohammed M, Hong, Michael P, Chen, Xinqi, Nassar, Majed S, Botros, Youssry Y, Cryns, Vincent L, Stoddart, J Fraser
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - toxicity
Cell Line, Tumor
Cell Survival - drug effects
Doxorubicin - chemistry
Doxorubicin - toxicity
Drug Carriers - chemistry
Drug delivery systems
Esterases - chemistry
Esterases - metabolism
Esters
Gating and risering
Human
Humans
Hydrogen-Ion Concentration
Liver
Nanoparticles
Nanoparticles - chemistry
Nanostructure
Polymers - chemistry
Porosity
Silicon dioxide
Silicon Dioxide - chemistry
Swine
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Beschreibung
Zusammenfassung:Gating of mesoporous silica nanoparticles (MSNs) with the stimuli-responsive poly(β-amino ester) has been achieved. This hybrid nanocarrier releases doxorubicin (DOX) under acidic conditions or in the presence of porcine liver esterase. The DOX loaded poly(β-amino ester)-capped MSNs reduce cell viability when tested on MDA-MB-231 human breast cancer cells.
ISSN:2040-3364
2040-3372
DOI:10.1039/c4nr07443b