ZnFe2O4 nanoparticles as radiosensitizers in radiotherapy of human prostate cancer cells
Nanoparticles of high-Z elements exhibit stronger photoelectric effects than soft tissues under gamma irradiation. Hence, they can be used as effective radiosensitizers for increasing the efficiency of current radiotherapy. In this work, superparamagnetic zinc ferrite spinel (ZnFe2O4) nanoparticles...
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Veröffentlicht in: | Materials Science & Engineering C 2015-01, Vol.46, p.394-399 |
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Sprache: | eng |
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Zusammenfassung: | Nanoparticles of high-Z elements exhibit stronger photoelectric effects than soft tissues under gamma irradiation. Hence, they can be used as effective radiosensitizers for increasing the efficiency of current radiotherapy. In this work, superparamagnetic zinc ferrite spinel (ZnFe2O4) nanoparticles were synthesized by a hydrothermal reaction method and used as radiosensitizers in cancer therapy. The magnetic nanoparticles showed fast separation from solutions (e.g., ~1min for 2mgmL−1 of the nanoparticles in ethanol) by applying an external magnetic field (~1T). The ZnFe2O4 nanoparticles were applied in an in vitro radiotherapy of lymph node carcinoma of prostate cells (as high radioresistant cells) under gamma irradiation of 60Co source. The nanoparticles exhibited no significant effects on the cancer cells up to the high concentration of 100μgmL−1, in the absence of gamma irradiation. The gamma irradiation alone (2Gy dose) also showed no significant effects on the cells. However, gamma irradiation in the presence of 100μgmL−1 ZnFe2O4 nanoparticles resulted in ~53% inactivation of the cells (~17 times higher than the inactivation that occurred under gamma irradiation alone) after 24h. The higher cell inactivation was assigned to interaction of gamma radiation with nanoparticles (photoelectric effect), resulting in a high level electron release in the media of the radioresistant cells. Our results indicated that ZnFe2O4 nanoparticles not only can be applied in increasing the efficiency of radiotherapy, but also can be easily separated from the cell environment by using an external magnetic field after the radiotherapy.
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•Synthesis of magnetic ZnFe2O4 nanoparticles with high-Z elements as radiosensitizers•Fast separation of the nanoparticles from solutions by applying a magnetic field•Application of the nanoparticles in efficient radiotherapy of radioresistant cancer cells |
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ISSN: | 0928-4931 1873-0191 |
DOI: | 10.1016/j.msec.2014.10.062 |