Screening for Ibuprofen-Sachharin Co-Crystal Formation in Wet Milling

Co-crystallization process has been used in pharmaceutical industry in producing new class of API solids due to its advantages such as physical stability and solubility.The objective of this study is to characterize the co-crystal formation of ibuprofen with saccharin as a co-crystal former through wet milling by using XRD, FTIR and DSC. A study of co-crystal formation from ibuprofen and saccharin has been conducted by using wet milling with the presence of solvent. The PXRD results showed a new phase which is believed a new crystalline has been successfully formed. The DSC analysis showed a new melting point for the new phase. However, the functional group assessment showed the presence of an unknown functional group in the system.