End tidal-to-arterial CO2 and O2 gas gradients at low- and high-altitude during dynamic end-tidal forcing

We sought to characterize and quantify the performance of a portable dynamic end-tidal forcing (DEF) system in controlling the partial pressure of arterial CO2 (Pa(CO2)) and O2 (Pa(O2)) at low (LA; 344 m) and high altitude (HA; 5,050 m) during an isooxic CO2 test and an isocapnic O2 test, which is c...

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Veröffentlicht in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2015-06, Vol.308 (11), p.R895-R906
Hauptverfasser: Tymko, Michael M, Ainslie, Philip N, MacLeod, David B, Willie, Chris K, Foster, Glen E
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Sprache:eng
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Zusammenfassung:We sought to characterize and quantify the performance of a portable dynamic end-tidal forcing (DEF) system in controlling the partial pressure of arterial CO2 (Pa(CO2)) and O2 (Pa(O2)) at low (LA; 344 m) and high altitude (HA; 5,050 m) during an isooxic CO2 test and an isocapnic O2 test, which is commonly used to measure ventilatory and vascular reactivity in humans (n = 9). The isooxic CO2 tests involved step changes in the partial pressure of end-tidal CO2 (PET(CO2)) of -10, -5, 0, +5, and +10 mmHg from baseline. The isocapnic O2 test consisted of a 10-min hypoxic step (PET(O2) = 47 mmHg) from baseline at LA and a 5-min euoxic step (PET(O2) = 100 mmHg) from baseline at HA. At both altitudes, PET(O2) and PET(CO2) were controlled within narrow limits (
ISSN:1522-1490
DOI:10.1152/ajpregu.00425.2014