Immune-mediated mechanisms influencing the efficacy of anticancer therapies

Immune-mediated mechanisms influencing the efficacy of anticancer therapies

Highlights • Anticancer therapies alter the composition, phenotype, and function of immune cells. • The immune system is a major regulator of the success of anticancer therapy. • Immunotherapy and immunomodulatory agents often synergize with conventional therapies. • Resistance mechanisms following...

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Veröffentlicht in:Trends in immunology 2015-04, Vol.36 (4), p.198-216
Hauptverfasser: Coffelt, Seth B, de Visser, Karin E
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Antineoplastic Agents - therapeutic use
Breast cancer
Chemotherapy
Humans
Immune system
Medical research
Neoplasms - drug therapy
Neoplasms - immunology
Neoplasms - pathology
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Zusammenfassung:Highlights • Anticancer therapies alter the composition, phenotype, and function of immune cells. • The immune system is a major regulator of the success of anticancer therapy. • Immunotherapy and immunomodulatory agents often synergize with conventional therapies. • Resistance mechanisms following immunotherapy and immunodulatory agents are not fully defined. • Targeting both cancer cells and immune cells may be the key to fight metastasis.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2015.02.006