Metabolism of hexachlorobenzene in the fry of steelhead trout, Salmo gairdneri (Oncorhynchus mykiss)

Dietary intake of hexachlorobenzene (HCB) by 10 g body weight steelhead trout fry, Salmo gairdneri, attained equilibrium in 12-14 d. On cessation of feeding, absorbed HCB was eliminated in 7 d. HCB was metabolized to low concentrations of pentachlorophenol (PCP) which conjugated with glucuronic acid...

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Veröffentlicht in:	Archives of environmental contamination and toxicology 1995-02, Vol.28 (2), p.209-214
Hauptverfasser:	Frankovic, L. (University of Illinois at Chicago, Chicago, IL.), Khan, M.A.Q, Ghais, S.M.A
Format:	Artikel
Sprache:	eng
Schlagworte:	ABSORCION ABSORPTION ACTIVIDAD ENZIMATICA ACTIVITE ENZYMATIQUE ADULT FISH Agnatha. Pisces ANIMAL DEVELOPMENTAL STAGES Animal, plant and microbial ecology APPLICATION METHODS Applied ecology Biological and medical sciences CYTOCHROME P-450 CYTOPLASMIC ORGANELLES Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates ENZYMIC ACTIVITY ETAPAS DEL DESARROLLO ANIMAL EXCRECION EXCRETION EXPERIMENTACION IN VITRO EXPERIMENTATION IN VITRO FARMACOLOGIA FOIE FONGICIDE Freshwater Fundamental and applied biological sciences. Psychology FUNGICIDAS FUNGICIDES HIGADO IN VITRO EXPERIMENTATION LIPIDE LIPIDOS LIPIDS LIVER METABOLISM METABOLISME METABOLISMO METALLOPROTEINE METALLOPROTEINS METALPROTEINAS METHODE D'APPLICATION METODOS DE APLICACION MICROSOMES ONCORHYNCHUS MYKISS ORAL ADMINISTRATION ORGANITE CELLULAIRE ORGANULOS CITOPLASMICOS PHARMACOKINETICS PHARMACOLOGIE PHARMACOLOGY RAINBOW TROUT STADE DE DEVELOPPEMENT ANIMAL
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Zusammenfassung:	Dietary intake of hexachlorobenzene (HCB) by 10 g body weight steelhead trout fry, Salmo gairdneri, attained equilibrium in 12-14 d. On cessation of feeding, absorbed HCB was eliminated in 7 d. HCB was metabolized to low concentrations of pentachlorophenol (PCP) which conjugated with glucuronic acid. PCP was also produced in-vitro by the hepatic microsomal P-450 of larger fry. Twenty days after exposure, 1 g fry showed traces only of 2,5-dichloro, 2,3,6-trichloro- and 2,4,5-trichlorophenol. There are 64 references.
ISSN:	0090-4341 1432-0703
DOI:	10.1007/BF00217618