Caloric restriction profoundly inhibits liver tumor formation after initiation by 6-nitrochrysene in male mice

Caloric restriction profoundly inhibits liver tumor formation after initiation by 6-nitrochrysene in male mice

Caloric restriction (CR) inhibited strongly the incidence of chemically-induced tumors in the neonatal B6C3F1 mouse tumorigenicity bioassay, when begun 3 months after treatment with the potent carcinogen 6-nitrochrysene. These data indicate that CR can have a profound inhibitory effect on tumor deve...

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Veröffentlicht in:Carcinogenesis (New York) 1994-02, Vol.15 (2), p.159-161
Hauptverfasser: Fu, Peter P., Dooley, Kenneth L., Von Tungeln, Linda S., Bucci, Thomas, Hart, Ronald W., Kadlubar, Fred F.
Format: Artikel
Sprache:eng
Schlagworte:
Adenoma - chemically induced
Adenoma - prevention & control
Animals
Biological and medical sciences
Biotransformation
Carcinogenesis, carcinogens and anticarcinogens
Carcinogens - pharmacokinetics
Chrysenes - pharmacokinetics
DNA Damage
Energy Intake
Food Deprivation
Foods and miscellaneous
Liver Neoplasms, Experimental - chemically induced
Liver Neoplasms, Experimental - prevention & control
Male
Medical sciences
Mice
Tumors
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Zusammenfassung:Caloric restriction (CR) inhibited strongly the incidence of chemically-induced tumors in the neonatal B6C3F1 mouse tumorigenicity bioassay, when begun 3 months after treatment with the potent carcinogen 6-nitrochrysene. These data indicate that CR can have a profound inhibitory effect on tumor development even long after metabolic activation and DNA repair have occurred.
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/15.2.159