Measuring Tissue Back-Pressure - In Vivo Injection Forces During Subcutaneous Injection

Purpose Limited information is available on injection forces of parenterals representing the in vivo situation. Scope of the present study was to investigate the contribution of the subcutaneous (sc) tissue layer to injection forces during in vivo injection. Methods Göttingen minipigs received injec...

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Veröffentlicht in:	Pharmaceutical research 2015-07, Vol.32 (7), p.2229-2240
Hauptverfasser:	Allmendinger, Andrea, Mueller, Robert, Schwarb, Edward, Chipperfield, Mark, Huwyler, Joerg, Mahler, Hanns-Christian, Fischer, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biomechanical Phenomena - physiology Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Dextrans - administration & dosage Dextrans - pharmacokinetics Drug Delivery Systems - instrumentation Equipment Design Hogs Injections Injections, Subcutaneous Male Medical Law Pharmaceutical sciences Pharmacology/Toxicology Pharmacy Pressure Research Paper Rheology Skin - metabolism Swine Swine, Miniature Tissue Distribution Viscosity
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