Gut healing: haemocytes aid via Sax and Tkv jazzes it down

Gut healing: haemocytes aid via Sax and Tkv jazzes it down

Control of stem cell activity is essential for accurate regeneration. Pathogen- or chemical-induced intestinal damage is now shown to recruit haemocytes expressing bone morphogenetic protein signals that stimulate proliferation of intestinal stem cells and subsequently induce their quiescence, in co...

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Veröffentlicht in:Nature cell biology 2015-06, Vol.17 (6), p.707-709
Hauptverfasser: Weaver, Lesley N., Drummond-Barbosa, Daniela
Format: Artikel
Sprache:eng
Schlagworte:
631/136/334/1582/715
631/136/532/2118/2437
631/136/532/489
Animals
Blood cells
Bone morphogenetic proteins
Cancer Research
Cell Biology
Cell research
Developmental Biology
Drosophila melanogaster - cytology
Genetic aspects
Hemocytes - cytology
Intestinal Mucosa - cytology
Life Sciences
news-and-views
Properties
Regeneration (Biology)
Stem Cells
Stem Cells - cytology
Tight Junctions - immunology
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Beschreibung
Zusammenfassung:Control of stem cell activity is essential for accurate regeneration. Pathogen- or chemical-induced intestinal damage is now shown to recruit haemocytes expressing bone morphogenetic protein signals that stimulate proliferation of intestinal stem cells and subsequently induce their quiescence, in conjunction with muscle-derived bone morphogenetic proteins. A temporal switch in expression of Type I receptors enables this two-phase response.
ISSN:1465-7392
1476-4679
DOI:10.1038/ncb3178