Indicators of the human immunodeficiency virus drug resistance to antiretroviral drugs in HIV-infected individuals in the Siberian Federal District in 2010-2012

Indicators of the human immunodeficiency virus drug resistance to antiretroviral drugs in HIV-infected individuals in the Siberian Federal District in 2010-2012

The prevalence of the mutations of resistance to the main three classes of antiretroviral agents in patients receiving antiretroviral therapy was tested. Among the main drug resistance mutations for the entire period of observation was a high frequency of the occurrence M184V mutation, K101E, K103N,...

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Veröffentlicht in:Voprosy virusologiĭ 2015, Vol.60 (1), p.20-23
Hauptverfasser: Kolomeets, A N, Dovgopolyuk, E S, Sergeeva, I V, Yastrebov, V K, Tyumentsev, A T
Format: Artikel
Sprache:rus
Schlagworte:
Drug Resistance, Viral - genetics
Female
HIV Infections - drug therapy
HIV Infections - genetics
HIV-1 - genetics
Humans
Male
Point Mutation
Reverse Transcriptase Inhibitors
Siberia
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Zusammenfassung:The prevalence of the mutations of resistance to the main three classes of antiretroviral agents in patients receiving antiretroviral therapy was tested. Among the main drug resistance mutations for the entire period of observation was a high frequency of the occurrence M184V mutation, K101E, K103N, Y181C, and G190S influencing the development of the HIV resistance to nucleoside and non-nucleoside reverse transcriptase inhibitors. The problems of the practical application of the study of HIV drug resistance in the regions of the Siberian Federal District were emphasized.
ISSN:0507-4088