Dihomo-γ-linolenic acid prevents the development of atopic dermatitis through prostaglandin D1 production in NC/Tnd mice

Highlights • DGLA containing diet suppressed the development of dermatitis in NC/Tnd mice. • Oral DGLA increased both PGD1 and PGD2 levels in the skin of the mice. • PGD1 levels were negatively correlated with the duration of scratching behavior. • Topical application of PGD1 significantly reduced i...

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Veröffentlicht in:	Journal of dermatological science 2015-07, Vol.79 (1), p.30-37
Hauptverfasser:	Amagai, Yosuke, Oida, Kumiko, Matsuda, Akira, Jung, Kyungsook, Kakutani, Saki, Tanaka, Takao, Matsuda, Kenshiro, Jang, Hyosun, Ahn, Ginae, Xia, Yan, Kawashima, Hiroshi, Shibata, Hiroshi, Matsuda, Hiroshi, Tanaka, Akane
Format:	Artikel
Sprache:	eng
Schlagworte:	8,11,14-Eicosatrienoic Acid - pharmacology 8,11,14-Eicosatrienoic Acid - therapeutic use Administration, Cutaneous Animals Arachidonic Acid - therapeutic use Atopic dermatitis Cell Degranulation Cytokines - genetics Dermatitis, Atopic - prevention & control Dermatology Dietary Supplements Dihomo-γ-linolenic acid Eicosapentaenoic Acid - therapeutic use Gene Expression - drug effects Mast Cells - drug effects Mast Cells - metabolism Mast Cells - physiology Mice NC/Tnd mouse Prostaglandin D1 Prostaglandin D2 - administration & dosage Prostaglandins D - biosynthesis RNA, Messenger - metabolism Up-Regulation
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Zusammenfassung:	Highlights • DGLA containing diet suppressed the development of dermatitis in NC/Tnd mice. • Oral DGLA increased both PGD1 and PGD2 levels in the skin of the mice. • PGD1 levels were negatively correlated with the duration of scratching behavior. • Topical application of PGD1 significantly reduced itching behavior. • Mast cells may be one of the important sources of PGD1 after DGLA application.
ISSN:	0923-1811 1873-569X
DOI:	10.1016/j.jdermsci.2015.03.010