Intramolecular oxidative coupling: I2/TBHP/NaN3-mediated synthesis of benzofuran derivatives

Intramolecular oxidative coupling: I2/TBHP/NaN3-mediated synthesis of benzofuran derivatives

A novel intramolecular oxidative coupling reaction has been established to prepare benzofuran derivatives via direct C(sp(2))-H functionalization for the formation of C-O bond. This transformation is mediated by I2/TBHP/NaN3 under metal-free conditions and a catalytic amount of NaN3 plays a crucial...

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Veröffentlicht in:Organic & biomolecular chemistry 2015-06, Vol.13 (22), p.6158-6161
Hauptverfasser: Xu, Wengang, Li, Qingcui, Cao, Chuanpeng, Zhang, Fanglin, Zheng, Hua
Format: Artikel
Sprache:eng
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Zusammenfassung:A novel intramolecular oxidative coupling reaction has been established to prepare benzofuran derivatives via direct C(sp(2))-H functionalization for the formation of C-O bond. This transformation is mediated by I2/TBHP/NaN3 under metal-free conditions and a catalytic amount of NaN3 plays a crucial role in the reaction. Furthermore, the reaction tolerates a broad substrate scope with average to excellent yields.
ISSN:1477-0539
DOI:10.1039/c5ob00577a