Cytotoxic hydroanthraquinones from the mangrove-derived fungus Paradictyoarthrinium diffractum BCC 8704
Two new hydroanthraquinones, paradictyoarthrins A ( 1 ) and B ( 2 ), were isolated from the mangrove-derived fungus Paradictyoarthrinium diffractum BCC 8704. Structures of the new compounds were elucidated by analyses of the NMR spectroscopic and mass spectrometry data. The absolute configuration of...
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| Veröffentlicht in: | Journal of antibiotics 2015-05, Vol.68 (5), p.334-338 |
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| container_issue | 5 |
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| container_title | Journal of antibiotics |
| container_volume | 68 |
| creator | Isaka, Masahiko Chinthanom, Panida Rachtawee, Pranee Srichomthong, Kitlada Srikitikulchai, Prasert Kongsaeree, Palangpon Prabpai, Samran |
| description | Two new hydroanthraquinones, paradictyoarthrins A (
1
) and B (
2
), were isolated from the mangrove-derived fungus
Paradictyoarthrinium diffractum
BCC 8704. Structures of the new compounds were elucidated by analyses of the NMR spectroscopic and mass spectrometry data. The absolute configuration of
1
was determined by X-ray crystallography. These compounds exhibited cytotoxic activities. |
| doi_str_mv | 10.1038/ja.2014.153 |
| format | Article |
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1
) and B (
2
), were isolated from the mangrove-derived fungus
Paradictyoarthrinium diffractum
BCC 8704. Structures of the new compounds were elucidated by analyses of the NMR spectroscopic and mass spectrometry data. The absolute configuration of
1
was determined by X-ray crystallography. These compounds exhibited cytotoxic activities.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.1038/ja.2014.153</identifier><identifier>PMID: 25407145</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>639/638/403/349 ; Anthraquinones - chemistry ; Anthraquinones - metabolism ; Ascomycota - metabolism ; Bacteriology ; Biomedical and Life Sciences ; Bioorganic Chemistry ; Crystallography ; Cytotoxicity ; Ecosystem ; Life Sciences ; Mass spectrometry ; Medicinal Chemistry ; Microbiology ; Models, Molecular ; Molecular Structure ; Organic Chemistry ; original-article</subject><ispartof>Journal of antibiotics, 2015-05, Vol.68 (5), p.334-338</ispartof><rights>Japan Antibiotics Research Association 2015</rights><rights>Copyright Nature Publishing Group May 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-5b76de50831db4470957b5583b80feff4584bf50f9642e0d567ba6c7276e04743</citedby><cites>FETCH-LOGICAL-c509t-5b76de50831db4470957b5583b80feff4584bf50f9642e0d567ba6c7276e04743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25407145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Isaka, Masahiko</creatorcontrib><creatorcontrib>Chinthanom, Panida</creatorcontrib><creatorcontrib>Rachtawee, Pranee</creatorcontrib><creatorcontrib>Srichomthong, Kitlada</creatorcontrib><creatorcontrib>Srikitikulchai, Prasert</creatorcontrib><creatorcontrib>Kongsaeree, Palangpon</creatorcontrib><creatorcontrib>Prabpai, Samran</creatorcontrib><title>Cytotoxic hydroanthraquinones from the mangrove-derived fungus Paradictyoarthrinium diffractum BCC 8704</title><title>Journal of antibiotics</title><addtitle>J Antibiot</addtitle><addtitle>J Antibiot (Tokyo)</addtitle><description>Two new hydroanthraquinones, paradictyoarthrins A (
1
) and B (
2
), were isolated from the mangrove-derived fungus
Paradictyoarthrinium diffractum
BCC 8704. Structures of the new compounds were elucidated by analyses of the NMR spectroscopic and mass spectrometry data. The absolute configuration of
1
was determined by X-ray crystallography. These compounds exhibited cytotoxic activities.</description><subject>639/638/403/349</subject><subject>Anthraquinones - chemistry</subject><subject>Anthraquinones - metabolism</subject><subject>Ascomycota - metabolism</subject><subject>Bacteriology</subject><subject>Biomedical and Life Sciences</subject><subject>Bioorganic Chemistry</subject><subject>Crystallography</subject><subject>Cytotoxicity</subject><subject>Ecosystem</subject><subject>Life Sciences</subject><subject>Mass spectrometry</subject><subject>Medicinal Chemistry</subject><subject>Microbiology</subject><subject>Models, Molecular</subject><subject>Molecular Structure</subject><subject>Organic Chemistry</subject><subject>original-article</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1r3DAQhkVoSTZpTr0XQy-F1tvRt3xsTb8g0B7as5AtaVfLWtqV7JD993WyaQkh5DQD88w7Aw9CrzEsMVD1cWOWBDBbYk5P0AIrhWvMRPMCLQAIrpUicIbOS9kAUEmlOkVnhDOQmPEFWrWHMY3pJvTV-mBzMnFcZ7OfQkzRlcrnNFTj2lWDiaucrl1tXQ7XzlZ-iqupVL9MNjb04yGZPG-GGKahssH7bPpxbj-3baUksFfopTfb4i7v6wX68_XL7_Z7ffXz24_201Xdc2jGmndSWMdBUWw7xiQ0XHacK9op8M57xhXrPAffCEYcWC5kZ0QviRQOmGT0Ar075u5y2k-ujHoIpXfbrYkuTUVjoajkjKpmRt8-QjdpynH-ThNKscCUKPwchaUSSklyl_X-SPU5lZKd17scBpMPGoO-taQ3Rt9a0rOlmX5znzl1g7P_2X9aZuDDESjzKK5cfnD0iby_z4KaOw</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Isaka, Masahiko</creator><creator>Chinthanom, Panida</creator><creator>Rachtawee, Pranee</creator><creator>Srichomthong, Kitlada</creator><creator>Srikitikulchai, Prasert</creator><creator>Kongsaeree, Palangpon</creator><creator>Prabpai, Samran</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150501</creationdate><title>Cytotoxic hydroanthraquinones from the mangrove-derived fungus Paradictyoarthrinium diffractum BCC 8704</title><author>Isaka, Masahiko ; 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1
) and B (
2
), were isolated from the mangrove-derived fungus
Paradictyoarthrinium diffractum
BCC 8704. Structures of the new compounds were elucidated by analyses of the NMR spectroscopic and mass spectrometry data. The absolute configuration of
1
was determined by X-ray crystallography. These compounds exhibited cytotoxic activities.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25407145</pmid><doi>10.1038/ja.2014.153</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of antibiotics, 2015-05, Vol.68 (5), p.334-338 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | 639/638/403/349 Anthraquinones - chemistry Anthraquinones - metabolism Ascomycota - metabolism Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Crystallography Cytotoxicity Ecosystem Life Sciences Mass spectrometry Medicinal Chemistry Microbiology Models, Molecular Molecular Structure Organic Chemistry original-article |
| title | Cytotoxic hydroanthraquinones from the mangrove-derived fungus Paradictyoarthrinium diffractum BCC 8704 |
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