Cytotoxic hydroanthraquinones from the mangrove-derived fungus Paradictyoarthrinium diffractum BCC 8704

Cytotoxic hydroanthraquinones from the mangrove-derived fungus Paradictyoarthrinium diffractum BCC 8704

Two new hydroanthraquinones, paradictyoarthrins A ( 1 ) and B ( 2 ), were isolated from the mangrove-derived fungus Paradictyoarthrinium diffractum BCC 8704. Structures of the new compounds were elucidated by analyses of the NMR spectroscopic and mass spectrometry data. The absolute configuration of...

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Veröffentlicht in:Journal of antibiotics 2015-05, Vol.68 (5), p.334-338
Hauptverfasser: Isaka, Masahiko, Chinthanom, Panida, Rachtawee, Pranee, Srichomthong, Kitlada, Srikitikulchai, Prasert, Kongsaeree, Palangpon, Prabpai, Samran
Format: Artikel
Sprache:eng
Schlagworte:
639/638/403/349
Anthraquinones - chemistry
Anthraquinones - metabolism
Ascomycota - metabolism
Bacteriology
Biomedical and Life Sciences
Bioorganic Chemistry
Crystallography
Cytotoxicity
Ecosystem
Life Sciences
Mass spectrometry
Medicinal Chemistry
Microbiology
Models, Molecular
Molecular Structure
Organic Chemistry
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Zusammenfassung:Two new hydroanthraquinones, paradictyoarthrins A ( 1 ) and B ( 2 ), were isolated from the mangrove-derived fungus Paradictyoarthrinium diffractum BCC 8704. Structures of the new compounds were elucidated by analyses of the NMR spectroscopic and mass spectrometry data. The absolute configuration of 1 was determined by X-ray crystallography. These compounds exhibited cytotoxic activities.
ISSN:0021-8820
1881-1469
DOI:10.1038/ja.2014.153