Oxidative damage and cell signaling transduction in patients of chronic myeloid leukemia

Chronic myeloid leukemia （CML） was the first human malignancy shown to be consistently associated with a chromosomal abnormality, the Philadelphia chromosome. At the gene level, the Philadelphia chromosome is the result of breaks on chromosomes 9 and 22 with a reciprocal translocation of the distal...

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Veröffentlicht in:	Acta biochimica et biophysica Sinica 2015-06, Vol.47 (6), p.474-476
Hauptverfasser:	Pande, Deepti, Negi, Reena, Karki, Kanchan, Khanna, Ranjana S, Khanna, Hari D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Female Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Oxidative Stress Signal Transduction 基因水平恶性肿瘤患者慢性粒细胞白血病染色体异常染色体断裂氧化损伤细胞信号转导
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Beschreibung
Zusammenfassung:	Chronic myeloid leukemia （CML） was the first human malignancy shown to be consistently associated with a chromosomal abnormality, the Philadelphia chromosome. At the gene level, the Philadelphia chromosome is the result of breaks on chromosomes 9 and 22 with a reciprocal translocation of the distal genetic material.
ISSN:	1672-9145 1745-7270
DOI:	10.1093/abbs/gmv029