The Mortality of Neonatal Herpes Simplex Virus Infection

The Mortality of Neonatal Herpes Simplex Virus Infection

This retrospective study characterized the clinical course of 13 neonates who died with herpes simplex virus infection from 2001 to 2011, representing a 26% case-fatality rate. Fatal disease developed at ≤48 hours of age in one-third of infants, was mostly disseminated disease, and occurred despite...

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Veröffentlicht in:The Journal of pediatrics 2015-06, Vol.166 (6), p.1529-1532.e1
Hauptverfasser: Lopez-Medina, Eduardo, MD, Cantey, Joseph B., MD, Sánchez, Pablo J., MD
Format: Artikel
Sprache:eng
Schlagworte:
Female
Herpes Simplex - diagnosis
Herpes Simplex - mortality
Humans
Infant, Newborn
Male
Pediatrics
Pregnancy Complications, Infectious - diagnosis
Pregnancy Complications, Infectious - mortality
Retrospective Studies
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Zusammenfassung:This retrospective study characterized the clinical course of 13 neonates who died with herpes simplex virus infection from 2001 to 2011, representing a 26% case-fatality rate. Fatal disease developed at ≤48 hours of age in one-third of infants, was mostly disseminated disease, and occurred despite early administration of high-dose acyclovir therapy.
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2015.03.004