Lack of induction of micronuclei by azidothymidine (AZT) in vivo in mouse bone marrow cells

Lack of induction of micronuclei by azidothymidine (AZT) in vivo in mouse bone marrow cells

AZT was tested for its ability to induce micronuclei (MN) in vivo in mouse bone marrow polychromatic erythrocytes (PCEs).

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Bibliographische Detailangaben
Veröffentlicht in:Environmental and molecular mutagenesis 1994, Vol.23 (1), p.74-76
Hauptverfasser: Motimaya, Ash M., Subramanya, Kevin S., Curry, Patrick T., Kitchin, Robert M.
Format: Artikel
Sprache:eng
Schlagworte:
Analysis of Variance
Animals
Biological and medical sciences
Bone Marrow - drug effects
Bone Marrow Cells
clastogenicity
cytotoxicity
dideoxynucleosides
Drug toxicity and drugs side effects treatment
Erythrocytes - drug effects
Female
Injections, Intraperitoneal
Male
Medical sciences
Mice
Micronucleus Tests
Mutagens - toxicity
normochromatic erythrocytes (NCEs)
Pharmacology. Drug treatments
polychromatic erythrocytes (PCEs)
Toxicity: osteoarticular system
Zidovudine - toxicity
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Zusammenfassung:AZT was tested for its ability to induce micronuclei (MN) in vivo in mouse bone marrow polychromatic erythrocytes (PCEs).
ISSN:0893-6692
1098-2280
DOI:10.1002/em.2850230112