The mannose-6-phosphate analogue, PXS64, inhibits fibrosis via TGF-β1 pathway in human lung fibroblasts

Highlights • PXS64 is a novel analogue of mannose-6-phosphate. • PXS64 reduces TGF-β1 driven fibrosis in NHLF cells, HF19 cells, and IPF patient lung fibroblasts. • Proteomics analysis with iTRAQ labelling showed that PXS64 specifically affects the TGF-β1 pathway.

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Veröffentlicht in:	Immunology letters 2015-06, Vol.165 (2), p.90-101
Hauptverfasser:	Schilter, Heidi, Cantemir-Stone, Carmen Z, Leksa, Vladimir, Ohradanova-Repic, Anna, Findlay, Alison D, Deodhar, Mandar, Stockinger, Hannes, Song, Xiaomin, Molloy, Mark, Marsh, Clay B, Jarolimek, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Airway Remodeling - drug effects Allergy and Immunology Animals Biological Availability Biomarkers - metabolism Cell Line Collagen - metabolism Fibroblasts Fibroblasts - drug effects Fibroblasts - immunology Fibronectins - metabolism Humans Idiopathic pulmonary fibrosis Idiopathic Pulmonary Fibrosis - drug therapy Insulin-Like Growth Factor II - genetics Lung - pathology M6P Mannose-6-phosphate Mannosephosphates - chemistry Mannosephosphates - therapeutic use Mannosides - chemistry Mannosides - therapeutic use Mice Mice, Knockout Organophosphonates - chemistry Organophosphonates - therapeutic use Prodrugs - chemical synthesis Prodrugs - pharmacology Proteomics PXS64 Signal Transduction Tenascin - metabolism TGF-β1 Transforming Growth Factor beta1 - immunology
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Beschreibung
Zusammenfassung:	Highlights • PXS64 is a novel analogue of mannose-6-phosphate. • PXS64 reduces TGF-β1 driven fibrosis in NHLF cells, HF19 cells, and IPF patient lung fibroblasts. • Proteomics analysis with iTRAQ labelling showed that PXS64 specifically affects the TGF-β1 pathway.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2015.04.003