Oxidative markers of Myeloperoxidase and Catalase and their diagnostic performance in bipolar disorder

Oxidative markers of Myeloperoxidase and Catalase and their diagnostic performance in bipolar disorder

Abstract Background Recent researches suggest oxidative stress and generalized inflammatory state to be associated with bipolar I disorder (BID). Our aim is to evaluate Myeloperoxidase (MPO) and Catalase (CAT) activities in BID. Methods 73 BID patients and 73 healthy controls were enrolled. Patients...

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Veröffentlicht in:Journal of affective disorders 2015-08, Vol.181, p.92-95
Hauptverfasser: Selek, Salih, Altindag, Abdurrahman, Saracoglu, Gulben, Aksoy, Nurten
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biomarkers - blood
Bipolar disorder
Bipolar Disorder - blood
Bipolar Disorder - diagnosis
Bipolar Disorder - enzymology
Bipolar Disorder - metabolism
Case-Control Studies
Catalase
Catalase - blood
Depression
Female
Humans
Inflammation - metabolism
Male
Mania
Myeloperoxidase
Oxidative Stress
Peroxidase - blood
Psychiatry
Young Adult
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Zusammenfassung:Abstract Background Recent researches suggest oxidative stress and generalized inflammatory state to be associated with bipolar I disorder (BID). Our aim is to evaluate Myeloperoxidase (MPO) and Catalase (CAT) activities in BID. Methods 73 BID patients and 73 healthy controls were enrolled. Patients were classified into manic, depressive and euthymic state. Serum MPO and CAT were measured in both patients and controls. Results CAT activity was significantly lower in controls than manic, depressive and euthymics ( p
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2015.03.058