Effect of the cephalosporin cefepime on hepatic drug metabolising enzyme activity in rats

Oral doses of the new cephalosporin cefepime administered to rats for 14 days (40 mg/kg/day) did not affect the activities of the hepatic drug metabolising enzymes measured. By contrast there were highly statistically significant increases in all measured parameters in rats treated with phenobarbito...

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Veröffentlicht in:	Toxicology letters 1994-03, Vol.71 (1), p.63-67
Hauptverfasser:	Jordan, M.C., Waller, A.R., Chasseaud, L.F., Barbhaiya, R.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	7-Alkoxycoumarin O-Dealkylase - metabolism Administration, Oral Aminopyrine N-Demethylase - metabolism Animals Biological and medical sciences Cefepime Cephalosporins Cephalosporins - administration & dosage Cephalosporins - toxicity Cytochrome P-450 Enzyme System - metabolism Drug toxicity and drugs side effects treatment Enzyme activity Enzyme Induction - drug effects Female Liver - drug effects Liver - enzymology Male Medical sciences Organ Size - drug effects Pharmacology. Drug treatments Rat Rats Rats, Sprague-Dawley Sex Characteristics Toxicity: digestive system
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Zusammenfassung:	Oral doses of the new cephalosporin cefepime administered to rats for 14 days (40 mg/kg/day) did not affect the activities of the hepatic drug metabolising enzymes measured. By contrast there were highly statistically significant increases in all measured parameters in rats treated with phenobarbitone (80 mg/kg/day), the positive control. Control activities in male rats exceeded those in females by about 2–3 fold.
ISSN:	0378-4274 1879-3169
DOI:	10.1016/0378-4274(94)90199-6