Synthesis of multiply substituted 1,6-dihydropyridines through Cu(I)-catalyzed 6-endo cyclization

Synthesis of multiply substituted 1,6-dihydropyridines through Cu(I)-catalyzed 6-endo cyclization

Copper-catalyzed 6-endo cyclization of N-propargylic β-enaminocarbonyls was developed for the synthesis of oxidation-labile 1,6-dihydropyridines. This synthetic method allows flexible and regio-defined assembly of various substituents at the N1, C2, C3, C4, and C6 positions of 1,6-dihydropyridines u...

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Veröffentlicht in:Organic & biomolecular chemistry 2015-06, Vol.13 (21), p.5955-5963
Hauptverfasser: Mizoguchi, Haruki, Watanabe, Ryo, Minami, Shintaro, Oikawa, Hideaki, Oguri, Hiroki
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Copper - chemistry
Cyclization
Dihydropyridines - chemical synthesis
Dihydropyridines - chemistry
Oxidation-Reduction
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Zusammenfassung:Copper-catalyzed 6-endo cyclization of N-propargylic β-enaminocarbonyls was developed for the synthesis of oxidation-labile 1,6-dihydropyridines. This synthetic method allows flexible and regio-defined assembly of various substituents at the N1, C2, C3, C4, and C6 positions of 1,6-dihydropyridines under mild conditions.
ISSN:1477-0520
1477-0539
DOI:10.1039/c5ob00356c