DNA Cleavage by 4-Alkynyl-3-methoxy-4-hydroxycyclobutenones

DNA Cleavage by 4-Alkynyl-3-methoxy-4-hydroxycyclobutenones

4-Alkynyl-3-methoxy-4-hydroxycyclobutenones, a readily available class of compounds, cleave supercoiled DNA by a mechanism that appears to require at least some involvement of diradical intermediates formed in the ring expansion of the cyclobutenones.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of organic chemistry 1994-05, Vol.59 (9), p.2276-2278
Hauptverfasser: Sullivan, Robert W, Coghlan, Vincent M, Munk, Stephen A, Moore, Harold W, Reed, Michael W
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:4-Alkynyl-3-methoxy-4-hydroxycyclobutenones, a readily available class of compounds, cleave supercoiled DNA by a mechanism that appears to require at least some involvement of diradical intermediates formed in the ring expansion of the cyclobutenones.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo00088a002