Anxiolytic efficacy of repeated oral capsaicin in rats with partial aberration of oral sensory relay to brain

Anxiolytic efficacy of repeated oral capsaicin in rats with partial aberration of oral sensory relay to brain

Highlights • Oral capsaicin improved anxiety behaviours of the lingual nerves transected rats. • Oral capsaicin increased stress axis activity of the lingual nerves transected rats. • Hippocampal neural plasticity may mediate the anxiolytic efficacy of oral capsaicin.

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Bibliographische Detailangaben
Veröffentlicht in:Archives of oral biology 2015-07, Vol.60 (7), p.989-997
Hauptverfasser: Choi, Young-Jun, Kim, Jin Young, Jin, Wei-Peng, Kim, Yoon-Tae, Lee, Jong-Ho, Jahng, Jeong Won
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Oral
Advanced Basic Science
Animals
Anxiety
Anxiety - drug therapy
Biomarkers - blood
Capsaicin - administration & dosage
Capsaicin - pharmacology
Chorda Tympani Nerve - surgery
Corticosterone
Corticosterone - blood
Dentistry
Lingual nerve
Lingual Nerve - surgery
Male
Oral sensory
Rats
Rats, Sprague-Dawley
Stress, Physiological
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Beschreibung
Zusammenfassung:Highlights • Oral capsaicin improved anxiety behaviours of the lingual nerves transected rats. • Oral capsaicin increased stress axis activity of the lingual nerves transected rats. • Hippocampal neural plasticity may mediate the anxiolytic efficacy of oral capsaicin.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2015.01.018