A Concise Synthesis of the Repeating Unit of Capsular Polysaccharide Staphylococcus aureus Type 8

A Concise Synthesis of the Repeating Unit of Capsular Polysaccharide Staphylococcus aureus Type 8

The first synthesis of the repeating unit of S. aureus capsular polysaccharide type 8 is described. The repeating unit is an unusual trisaccharide sequence of three uncommon sugars, all connected via 1,2-cis linkages. The synthetic trisaccharide was equipped with capping methyl groups at the points...

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Veröffentlicht in:Organic letters 2015-05, Vol.17 (10), p.2382-2384
Hauptverfasser: Visansirikul, Satsawat, Yasomanee, Jagodige P, Pornsuriyasak, Papapida, Kamat, Medha N, Podvalnyy, Nikita M, Gobble, Chase P, Thompson, Melissa, Kolodziej, Stephen A, Demchenko, Alexei V
Format: Artikel
Sprache:eng
Schlagworte:
Carbohydrate Conformation
Carbohydrate Sequence
Polysaccharides, Bacterial - chemical synthesis
Polysaccharides, Bacterial - chemistry
Staphylococcus aureus - chemistry
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Zusammenfassung:The first synthesis of the repeating unit of S. aureus capsular polysaccharide type 8 is described. The repeating unit is an unusual trisaccharide sequence of three uncommon sugars, all connected via 1,2-cis linkages. The synthetic trisaccharide was equipped with capping methyl groups at the points of propagation of the polysaccharide sequence.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.5b00899