Evaluation of urinary microRNA panel in bladder cancer diagnosis: relation to bilharziasis

We assessed the differential expression of a urinary panel of microRNAs (miRs) in terms of potential application as diagnostic markers of bladder cancer (BC) and relationship to bilharziasis. We investigated voided urine samples and blood from patients with BC (n = 188), benign bladder lesions (n = ...

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Veröffentlicht in:Translational research : the journal of laboratory and clinical medicine 2015-06, Vol.165 (6), p.731-739
Hauptverfasser: Eissa, Sanaa, Matboli, Marwa, Hegazy, Marwa G.A, Kotb, Youssef M, Essawy, Nada O.E
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Sprache:eng
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Zusammenfassung:We assessed the differential expression of a urinary panel of microRNAs (miRs) in terms of potential application as diagnostic markers of bladder cancer (BC) and relationship to bilharziasis. We investigated voided urine samples and blood from patients with BC (n = 188), benign bladder lesions (n = 88), and age-matched controls (n = 92). Five miRs (miR-210, miR-10b, miR-29c, miR-221, and miR-23a) were selected from previous microarray signature profiling (released by miR2Disease). Afterward, they were validated using polymerase chain reaction array. The expression levels of miR-210, miR-10b, and miR-29c in the urine samples were significantly higher in BC ( P  
ISSN:1931-5244
1878-1810
DOI:10.1016/j.trsl.2014.12.008