L-type calcium channels mediate dynorphin neuropeptide release from dendrites but not axons of hippocampal granule cells
Granule cells in the guinea pig dentate gyrus release κ opioid neuropeptides, dynorphins, from dendrites as well as from axon terminals. We have found that both L- and N-type calcium channel antagonists inhibited dendritic dynorphin release. In contrast, N-type but not L-type calcium channel antagon...
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Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 1995-06, Vol.14 (6), p.1265-1272 |
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Sprache: | eng |
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Zusammenfassung: | Granule cells in the guinea pig dentate gyrus release κ opioid neuropeptides, dynorphins, from dendrites as well as from axon terminals. We have found that both L- and N-type calcium channel antagonists inhibited dendritic dynorphin release. In contrast, N-type but not L-type calcium channel antagonists inhibited axonal dynorphin release. Neither L- nor N-type channel antagonists directly altered the effects of κ opioid receptor activation. By inhibiting dynorphin release, L-type channel antagonists also facilitated the induction of long-term potentiation of the perforant path-granule cell synapse. These studies establish that a single cell type can release a transmitter from two different cellular domains and provide new distinction between axonal and dendritic transmitter release mechanisms. |
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ISSN: | 0896-6273 1097-4199 |
DOI: | 10.1016/0896-6273(95)90273-2 |