A secreted calreticulin protein in ixodid tick ( Amblyomma americanum) saliva

A complementary DNA clone from salivary glands of feeding female Amblyomma americanum ticks has been characterized as encoding calreticulin. Calreticulin, a major endoplasmic reticulum (ER) calcium-binding protein, appears to be secreted in Amblyomma and Dermacentor saliva. Evidence is accummulating...

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Veröffentlicht in:Journal of insect physiology 1995-04, Vol.41 (4), p.369-375
Hauptverfasser: Jaworski, Deborah C., Simmen, Frank A., Lamoreaux, William, Coons, Lewis B., Muller, Mark T., Needham, Glen R.
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Sprache:eng
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Zusammenfassung:A complementary DNA clone from salivary glands of feeding female Amblyomma americanum ticks has been characterized as encoding calreticulin. Calreticulin, a major endoplasmic reticulum (ER) calcium-binding protein, appears to be secreted in Amblyomma and Dermacentor saliva. Evidence is accummulating that calreticulin performs roles unrelated to calcium storage. Unlike most known calreticulins, tick-secreted calreticulin lacks the ER retention signal, KDEL. This is the first molecular cloning of a specific tick salivary gland protein. The finding of a secreted calreticulin in tick saliva suggests a role for calreticulin in blood feeding through host immunosuppression or antihemostasis.
ISSN:0022-1910
1879-1611
DOI:10.1016/0022-1910(94)00107-R