Induction of apoptosis by parthenolide in human oral cancer cell lines and tumor xenografts

Highlights • Parthenolide (PTL) induces caspase-mediated apoptosis in human oral cancer cell lines. • PTL augments Bim protein by enhancing either Bim mRNA or its protein stability. • PTL also induces death receptor 5 accompanied with caspase 8 and truncated Bid. • PTL suppresses tumor growth throug...

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Veröffentlicht in:	Oral oncology 2015-06, Vol.51 (6), p.602-609
Hauptverfasser:	Yu, Hyun-Ju, Jung, Ji-Youn, Jeong, Joseph H, Cho, Sung-Dae, Lee, Jeong-Sang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Bcl-2-Like Protein 11 BH3 Interacting Domain Death Agonist Protein - metabolism Bim Caspase 3 - metabolism Caspase 8 - metabolism Cell Line, Tumor Death receptor 5 Female Hematology, Oncology and Palliative Medicine Humans Membrane Proteins - metabolism Mice Mice, Nude Mitochondria - metabolism Mouth Neoplasms - metabolism Oral cancer Otolaryngology Parthenolide Poly(ADP-ribose) Polymerases - metabolism Proto-Oncogene Proteins - metabolism Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism RNA, Messenger - metabolism RNA, Small Interfering - metabolism Sesquiterpenes - pharmacology
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Zusammenfassung:	Highlights • Parthenolide (PTL) induces caspase-mediated apoptosis in human oral cancer cell lines. • PTL augments Bim protein by enhancing either Bim mRNA or its protein stability. • PTL also induces death receptor 5 accompanied with caspase 8 and truncated Bid. • PTL suppresses tumor growth through apoptosis in nude mice tumor xenograft. • There are no abnormal histopathological findings in normal organs upon PTL treatment.
ISSN:	1368-8375 1879-0593
DOI:	10.1016/j.oraloncology.2015.03.003