Effect of allicin on DNA damage and oxidative stress of human peripheral blood cell induced by exhaustive exercise

Objective: This study was performed to determine the effect of allicin against DNA damage and oxidative stress on human peripheral blood cell after exhaustive exercise, and discuss the protective mechanism of allicin. Methods: 16 male athletes (aged 21.06 plus or minus 1.02 years), in a randomized and double-blind design were allocated in two equal supplement and placebo groups (80mg/day allicin for 14 days). After supplementation, all participants were participated in Bruce test. The blood samples were taken in three phases (before and after the supplementation and after the exercise). The DNA damage was investigated on human peripheral blood cell by using the single cell gel electrophoresis (SCGE) and the level of SOD, GSH and MDA was detected in serum. Results: During the first two phases(before and after the supplementation), the level of DNA damage and the status of SOD, GSH and MDA between supplement and placebo groups did not show significant difference(P > 0.05). Moreover, exercise-induced decrease of