Ribifolin, an Orbitide from Jatropha ribifolia, and Its Potential Antimalarial Activity

Ribifolin, an Orbitide from Jatropha ribifolia, and Its Potential Antimalarial Activity

A new orbitide named ribifolin was isolated and characterized from Jatropha ribifolia using mass spectrometry, NMR spectroscopy, quantitative amino acid analysis, molecular dynamics/simulated annealing, and Raman optical activity measurements and calculations. Ribifolin (1) and its linear form (1a)...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2015-03, Vol.78 (3), p.374-380
Hauptverfasser: Pinto, Meri Emili F, Batista, João M, Koehbach, Johannes, Gaur, Pratibha, Sharma, Abhinay, Nakabashi, Myna, Cilli, Eduardo Maffud, Giesel, Guilherme M, Verli, Hugo, Gruber, Christian W, Blanch, Ewan W, Tavares, Joseam F, Silva, Marcelo S. da, Garcia, Celia R. S, Bolzani, Vanderlan S
Format: Artikel
Sprache:eng
Schlagworte:
Antimalarials - chemistry
Antimalarials - isolation & purification
Antimalarials - pharmacology
Drug Screening Assays, Antitumor
Jatropha
Jatropha - chemistry
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Parasitic Sensitivity Tests
Peptides, Cyclic - chemistry
Peptides, Cyclic - isolation & purification
Peptides, Cyclic - pharmacology
Plant Extracts - chemistry
Plasmodium falciparum
Plasmodium falciparum - drug effects
Solid-Phase Synthesis Techniques
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Zusammenfassung:A new orbitide named ribifolin was isolated and characterized from Jatropha ribifolia using mass spectrometry, NMR spectroscopy, quantitative amino acid analysis, molecular dynamics/simulated annealing, and Raman optical activity measurements and calculations. Ribifolin (1) and its linear form (1a) were synthesized by solid-phase peptide synthesis, followed by evaluation of its antiplasmodial and cytotoxicity activities. Compound 1 was moderately effective (IC50 = 42 μM) against the Plasmodium falciparum strain 3D7.
ISSN:0163-3864
1520-6025
DOI:10.1021/np5007668