The detection of viral and atypical pathogens in children with acute respiratory infection

This paper aims to investigate the viral and atypical pathogens in children with acute respiratory infection (ART). A total of 17 048 serum samples were collected from children, who were intended to diagnose as ART. Indirect immunofluorescence assays were performed to detect IgM antibodies against 9 common pathogens, including mycoplasma pneumonia(MP), influenza virus B (FluB) respiratory syncytial virus (RSV), parainfluenza virus (PTV), adenovirus (ADV), influenza A. virus (FIuA), legionella pneumophila(LPN), coxiella burnetii (COX), chamydophila pneumonia (CPn). The most common pathogens causing ARI in children of Wuhan were MP, FluB and RSV. The detection rate of each pathogen displayed specific seasonal variations and variations among different age groups. Mixed infections were more common than single infections, and the most common pattern was MP + FluB.