Polymorphisms within ASTN2 gene are associated with age at onset of Alzheimer’s disease

Alzheimer’s disease (AD) is a multifactorial neurological condition associated with genetic profiles that are still not completely understood. We performed a family-based low-density genome-wide association analysis of age at onset (AAO) in AD (244 patients and their relatives) using Illumina 6 K si...

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Veröffentlicht in:	Journal of Neural Transmission 2015-05, Vol.122 (5), p.701-708
Hauptverfasser:	Wang, Ke-Sheng, Tonarelli, Silvina, Luo, Xingguang, Wang, Liang, Su, Brenda, Zuo, Lingjun, Mao, ChunXiang, Rubin, Lewis, Briones, David, Xu, Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age of Onset Aged Aged, 80 and over Alzheimer Disease - genetics Canada Genome-Wide Association Study Genotype Glycoproteins - genetics Humans Kaplan-Meier Estimate Linkage Disequilibrium Medicine Medicine & Public Health Middle Aged Nerve Tissue Proteins - genetics Neurology Neurology and Preclinical Neurological Studies - Original Article Neurosciences Polymorphism, Single Nucleotide Psychiatry
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Zusammenfassung:	Alzheimer’s disease (AD) is a multifactorial neurological condition associated with genetic profiles that are still not completely understood. We performed a family-based low-density genome-wide association analysis of age at onset (AAO) in AD (244 patients and their relatives) using Illumina 6 K single-nucleotide polymorphisms (SNPs) panel and the FBAT-logrank statistic. We observed 10 SNPs associated with AAO in AD with p
ISSN:	0300-9564 1435-1463
DOI:	10.1007/s00702-014-1306-z