Exercise-mediated changes in high-density lipoprotein: Impact on form and function

The goal of this systematic review was to assess the current understanding of the effects of exercise intervention on high-density lipoprotein (HDL) cholesterol (HDL-C) and changes in HDL function as well as modification of these effects by genomic factors. The reviewed studies demonstrate that exer...

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Veröffentlicht in:The American heart journal 2013-09, Vol.166 (3), p.392-400
Hauptverfasser: Blazek, Alisa, MA, Rutsky, Jessica, BA, Osei, Kwame, MD, Maiseyeu, Andrei, PhD, Rajagopalan, Sanjay, MD
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Sprache:eng
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Zusammenfassung:The goal of this systematic review was to assess the current understanding of the effects of exercise intervention on high-density lipoprotein (HDL) cholesterol (HDL-C) and changes in HDL function as well as modification of these effects by genomic factors. The reviewed studies demonstrate that exercise has modest effects on HDL-C with limited data suggesting an effect on HDL function. Genetic polymorphisms in proteins associated with HDL metabolism play a role in modifying the HDL-C response to exercise and possibly its function. Exercise as an intervention for patients at risk for cardiovascular events can lead to small improvements in HDL-C and potential changes in HDL function. There is an important modifier effect of genetics in determining these changes.
ISSN:0002-8703
1097-6744
DOI:10.1016/j.ahj.2013.05.021