Exercise-mediated changes in high-density lipoprotein: Impact on form and function
The goal of this systematic review was to assess the current understanding of the effects of exercise intervention on high-density lipoprotein (HDL) cholesterol (HDL-C) and changes in HDL function as well as modification of these effects by genomic factors. The reviewed studies demonstrate that exer...
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Veröffentlicht in: | The American heart journal 2013-09, Vol.166 (3), p.392-400 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The goal of this systematic review was to assess the current understanding of the effects of exercise intervention on high-density lipoprotein (HDL) cholesterol (HDL-C) and changes in HDL function as well as modification of these effects by genomic factors. The reviewed studies demonstrate that exercise has modest effects on HDL-C with limited data suggesting an effect on HDL function. Genetic polymorphisms in proteins associated with HDL metabolism play a role in modifying the HDL-C response to exercise and possibly its function. Exercise as an intervention for patients at risk for cardiovascular events can lead to small improvements in HDL-C and potential changes in HDL function. There is an important modifier effect of genetics in determining these changes. |
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ISSN: | 0002-8703 1097-6744 |
DOI: | 10.1016/j.ahj.2013.05.021 |