Levels of 4-1BB transcripts and soluble 4-1BB protein are elevated in the adipose tissue of human obese subjects and are associated with inflammatory and metabolic parameters

Background: 4-1BB, a member of the TNF receptor superfamily, has a role in various inflammatory pathologies through its interaction with 4-1BB ligand. We previously demonstrated that it participates in initiating and promoting obesity-induced adipose inflammation in a rodent model. Objective: In thi...

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Veröffentlicht in:	International Journal of Obesity 2014-08, Vol.38 (8), p.1075-1082
Hauptverfasser:	Tu, T H, Kim, C-S, Kang, J-H, Nam-Goong, I S, Nam, C W, Kim, E S, Kim, Y I, Choi, J I, Kawada, T, Goto, T, Park, T, Yoon Park, J H, Choi, M-S, Yu, R
Format:	Artikel
Sprache:	eng
Schlagworte:	4-1BB Ligand - metabolism 631/250/256 692/53 692/699/2743/2037 692/699/2743/393 Adipocytes Adipocytes - metabolism Adipose tissue Adipose Tissue - immunology Adipose Tissue - metabolism Adipose tissues Biological and medical sciences Biomarkers Body fat Body Mass Index Body size Cells, Cultured Complications and side effects Enzyme-Linked Immunosorbent Assay Epidemiology Female Genetic aspects Health Promotion and Disease Prevention Humans Immunoassay Inflammation Inflammation - immunology Inflammation - metabolism Insulin resistance Internal Medicine Lymphocytes Lymphocytes T Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Metabolic disorders Metabolic syndrome Metabolism Miscellaneous Monocytes Nutrition Obesity Obesity - immunology Obesity - metabolism Obesity - physiopathology original-article Other metabolic disorders Parameters Proteins Public Health Real-Time Polymerase Chain Reaction Rodents Solubility Therapeutic targets Tumor necrosis factor Tumor Necrosis Factor Receptor Superfamily, Member 9 - metabolism Tumor necrosis factor receptors
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Zusammenfassung:	Background: 4-1BB, a member of the TNF receptor superfamily, has a role in various inflammatory pathologies through its interaction with 4-1BB ligand. We previously demonstrated that it participates in initiating and promoting obesity-induced adipose inflammation in a rodent model. Objective: In this study, we examined whether 4-1BB is related to obesity-induced adipose inflammation and metabolic parameters in humans. Methods: A total of 50 subjects, 25 obese (body mass index (BMI)⩾25 kg m −2 ) and 25 lean (BMI
ISSN:	0307-0565 1476-5497
DOI:	10.1038/ijo.2013.222