Genetic polymorphisms in the one-carbon metabolism pathway genes and susceptibility to non-Hodgkin lymphoma

Corroborating evidence related to the role of aberrations on one-carbon metabolism (OCM) genes has been inconsistent. We evaluated the association between polymorphisms in 12 single nucleotide polymorphisms (SNPs) in 8 OCM genes (CBS, FPGS, FTHFD, MTRR, SHMT1, SLC19A1, TCN1, and TYMS), and non-Hodgkin lymphoma (NHL) risk in a multi-ethnic population which includes Malay, Chinese and Indian ethnic subgroups. Cases ( N = 372) and controls ( N = 722) were genotyped using the Sequenom MassARRAY platform. Our results of the pooled subjects showed a significantly enhanced NHL risk for CBS Ex9 + 33C > T (T versus C: OR 1.55, 95 % CI 1.22–1.96, P = 0.0003), CBS Ex18-319G > A (A versus G: OR 1.15, 95 % CI 1.14–1.83; P = 0.002), SHMT1 Ex12 + 236 T > C (T versus C: OR 1.44, 95 % CI 1.15–1.81, P = 0.002), and TYMS Ex8 + 157C > T (T versus C: OR 1.29, 95 % CI 1.06–1.57, P = 0.01). Haplotype analysis for CBS SNPs showed a significantly decreased risk of NHL in subjects with haplotype CG (OR 0.69, 95 % CI 0.56–0.86, P =