Differential gene expression profiles of two excitable rat cell lines after over-expression of WT- and C121W-β1 sodium channel subunits

Highlights • β1 subunit modifies the expression of different gene sets of GH3 and H9C2 cells. • Epileptogenic C121W mutation causes tissue-specific gene expression changes. • C121W-β1 modifies genes involved in Cellular Communication and Protein Expression.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2015-06, Vol.297, p.105-117
Hauptverfasser:	Baroni, D, Moran, O
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Transformed Cysteine - genetics DNA-microarray epilepsy gene expression Gene Expression Profiling Microarray Analysis mRNA Mutation - genetics Neurology Rats RNA, Messenger - metabolism Transfection Tryptophan - genetics voltage-gated sodium channel Voltage-Gated Sodium Channel beta-1 Subunit - genetics Voltage-Gated Sodium Channel beta-1 Subunit - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • β1 subunit modifies the expression of different gene sets of GH3 and H9C2 cells. • Epileptogenic C121W mutation causes tissue-specific gene expression changes. • C121W-β1 modifies genes involved in Cellular Communication and Protein Expression.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.03.052