SnapShot: Insulin/IGF1 Signaling

SnapShot: Insulin/IGF1 Signaling

The insulin/IGF1signaling pathway (ISP) plays an essential role in long-term health. Some perturbations in this pathway are associated with diseases such as type 2 diabetes; other perturbations extend lifespan in worms, flies, and mice. The ISP regulates many biological processes, including energy s...

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Veröffentlicht in:Cell 2015-05, Vol.161 (4), p.948-948.e1
Hauptverfasser: Ma, David K.G., Stolte, Christian, Krycer, James R., James, David E., O’Donoghue, Seán I.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Humans
Insulin - metabolism
Insulin-Like Growth Factor I - metabolism
Phosphorylation
Proteins - metabolism
Signal Transduction
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Beschreibung
Zusammenfassung:The insulin/IGF1signaling pathway (ISP) plays an essential role in long-term health. Some perturbations in this pathway are associated with diseases such as type 2 diabetes; other perturbations extend lifespan in worms, flies, and mice. The ISP regulates many biological processes, including energy storage, apoptosis, transcription, and cellular homeostasis. Such regulation involves precise rewiring of temporal events in protein phosphorylation networks. For an animated version of this Enhanced SnapShot, please visit http://www.cell.com/cell/enhanced/odonoghue.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2015.04.041