Brown adipose tissue and novel therapeutic approaches to treat metabolic disorders
In humans, 2 functionally different types of adipose tissue coexist: white adipose tissue (WAT) and brown adipose tissue (BAT). WAT is involved in energy storage, whereas BAT is involved in energy expenditure. Increased amounts of WAT may contribute to the development of metabolic disorders, such as...
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| Veröffentlicht in: | Translational research : the journal of laboratory and clinical medicine 2015-04, Vol.165 (4), p.464-479 |
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| container_title | Translational research : the journal of laboratory and clinical medicine |
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| creator | Roman, Sabiniano Agil, Ahmad Peran, Macarena Alvaro-Galue, Eduardo Ruiz-Ojeda, Francisco J Fernández-Vázquez, Gumersindo Marchal, Juan A |
| description | In humans, 2 functionally different types of adipose tissue coexist: white adipose tissue (WAT) and brown adipose tissue (BAT). WAT is involved in energy storage, whereas BAT is involved in energy expenditure. Increased amounts of WAT may contribute to the development of metabolic disorders, such as obesity-associated type 2 diabetes mellitus and cardiovascular diseases. In contrast, the thermogenic function of BAT allows high consumption of fatty acids because of the activity of uncoupling protein 1 in the internal mitochondrial membrane. Interestingly, obesity reduction and insulin sensitization have been achieved by BAT activation-regeneration in animal models. This review describes the origin, function, and differentiation mechanisms of BAT to identify new therapeutic strategies for the treatment of metabolic disorders related to obesity. On the basis of the animal studies, novel approaches for BAT regeneration combining stem cells from the adipose tissue with active components, such as melatonin, may have potential for the treatment of metabolic disorders in humans. |
| doi_str_mv | 10.1016/j.trsl.2014.11.002 |
| format | Article |
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WAT is involved in energy storage, whereas BAT is involved in energy expenditure. Increased amounts of WAT may contribute to the development of metabolic disorders, such as obesity-associated type 2 diabetes mellitus and cardiovascular diseases. In contrast, the thermogenic function of BAT allows high consumption of fatty acids because of the activity of uncoupling protein 1 in the internal mitochondrial membrane. Interestingly, obesity reduction and insulin sensitization have been achieved by BAT activation-regeneration in animal models. This review describes the origin, function, and differentiation mechanisms of BAT to identify new therapeutic strategies for the treatment of metabolic disorders related to obesity. 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WAT is involved in energy storage, whereas BAT is involved in energy expenditure. Increased amounts of WAT may contribute to the development of metabolic disorders, such as obesity-associated type 2 diabetes mellitus and cardiovascular diseases. In contrast, the thermogenic function of BAT allows high consumption of fatty acids because of the activity of uncoupling protein 1 in the internal mitochondrial membrane. Interestingly, obesity reduction and insulin sensitization have been achieved by BAT activation-regeneration in animal models. This review describes the origin, function, and differentiation mechanisms of BAT to identify new therapeutic strategies for the treatment of metabolic disorders related to obesity. On the basis of the animal studies, novel approaches for BAT regeneration combining stem cells from the adipose tissue with active components, such as melatonin, may have potential for the treatment of metabolic disorders in humans.</description><subject>Adipocytes, Brown - physiology</subject><subject>Adipose Tissue, Brown - metabolism</subject><subject>Animals</subject><subject>Cardiovascular Diseases - complications</subject><subject>Cardiovascular Diseases - metabolism</subject><subject>Diabetes Mellitus, Type 2 - etiology</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Obesity - complications</subject><subject>Obesity - metabolism</subject><issn>1931-5244</issn><issn>1878-1810</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2L1jAUhYsozjj6B1xIlm5abz7apiCCM_gFA4If65Amt0xe-zY1Nx2Zf2_KO7pw4SoXcs7h3udU1XMODQfevTo0OdHcCOCq4bwBEA-qc657XXPN4WGZB8nrVih1Vj0hOgCobgD1uDoTrZJS6OG8-nKZ4q-FWR_WSMhyINqQ2cWzJd7izPINJrviloNjdl1TtO4GieXIckKb2RGzHeNcfn2gmDwmelo9muxM-Oz-vai-v3_37epjff35w6ert9e1a1Wfa9uNqEGPwwRCt8LCCK3ykx-EnZRzXDgYnO6E7FspegCUEwqvZTu1oxtsLy-ql6fcstXPDSmbYyCH82wXjBsZ3mkoNEAORSpOUpciUcLJrCkcbbozHMzO0hzMztLsLA3nprAsphf3-dt4RP_X8gdeEbw-CbBceRswGXIBF4c-JHTZ-Bj-n__mH7ubwxKcnX_gHdIhbmkp_Aw3JAyYr3ube5lclSKh5_I3xYya-w</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Roman, Sabiniano</creator><creator>Agil, Ahmad</creator><creator>Peran, Macarena</creator><creator>Alvaro-Galue, Eduardo</creator><creator>Ruiz-Ojeda, Francisco J</creator><creator>Fernández-Vázquez, Gumersindo</creator><creator>Marchal, Juan A</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4996-8261</orcidid></search><sort><creationdate>20150401</creationdate><title>Brown adipose tissue and novel therapeutic approaches to treat metabolic disorders</title><author>Roman, Sabiniano ; Agil, Ahmad ; Peran, Macarena ; Alvaro-Galue, Eduardo ; Ruiz-Ojeda, Francisco J ; Fernández-Vázquez, Gumersindo ; Marchal, Juan A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-a6be808b9f02852a0b054dfd92af4cc12c09c86237532700e3fe2d835f5bc9a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adipocytes, Brown - physiology</topic><topic>Adipose Tissue, Brown - metabolism</topic><topic>Animals</topic><topic>Cardiovascular Diseases - complications</topic><topic>Cardiovascular Diseases - metabolism</topic><topic>Diabetes Mellitus, Type 2 - etiology</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Obesity - complications</topic><topic>Obesity - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roman, Sabiniano</creatorcontrib><creatorcontrib>Agil, Ahmad</creatorcontrib><creatorcontrib>Peran, Macarena</creatorcontrib><creatorcontrib>Alvaro-Galue, Eduardo</creatorcontrib><creatorcontrib>Ruiz-Ojeda, Francisco J</creatorcontrib><creatorcontrib>Fernández-Vázquez, Gumersindo</creatorcontrib><creatorcontrib>Marchal, Juan A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Translational research : the journal of laboratory and clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roman, Sabiniano</au><au>Agil, Ahmad</au><au>Peran, Macarena</au><au>Alvaro-Galue, Eduardo</au><au>Ruiz-Ojeda, Francisco J</au><au>Fernández-Vázquez, Gumersindo</au><au>Marchal, Juan A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brown adipose tissue and novel therapeutic approaches to treat metabolic disorders</atitle><jtitle>Translational research : the journal of laboratory and clinical medicine</jtitle><addtitle>Transl Res</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>165</volume><issue>4</issue><spage>464</spage><epage>479</epage><pages>464-479</pages><issn>1931-5244</issn><eissn>1878-1810</eissn><abstract>In humans, 2 functionally different types of adipose tissue coexist: white adipose tissue (WAT) and brown adipose tissue (BAT). 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| identifier | ISSN: 1931-5244 |
| ispartof | Translational research : the journal of laboratory and clinical medicine, 2015-04, Vol.165 (4), p.464-479 |
| issn | 1931-5244 1878-1810 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adipocytes, Brown - physiology Adipose Tissue, Brown - metabolism Animals Cardiovascular Diseases - complications Cardiovascular Diseases - metabolism Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - metabolism Humans Internal Medicine Obesity - complications Obesity - metabolism |
| title | Brown adipose tissue and novel therapeutic approaches to treat metabolic disorders |
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