Copper-catalyzed cascade addition/cyclization: highly efficient access to phosphonylated quinoline-2,4(1H,3H)-diones

Copper-catalyzed cascade addition/cyclization: highly efficient access to phosphonylated quinoline-2,4(1H,3H)-diones

A novel and facile Cu-catalyzed addition/cyclization cascade of o-cyanoarylacrylamide was developed. The process exhibits significant functional group tolerance, and provides an efficient and straightforward pathway for the synthesis of various phosphonylated quinoline-2,4(1H,3H)-diones.

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Veröffentlicht in:Organic & biomolecular chemistry 2015-05, Vol.13 (19), p.5376-5380
Hauptverfasser: Li, Ya-Min, Wang, Shi-Sheng, Yu, Fuchao, Shen, Yuehai, Chang, Kwen-Jen
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Copper - chemistry
Cyclization
Free Radicals - chemistry
Phosphorous Acids - chemistry
Quinolines - chemistry
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Zusammenfassung:A novel and facile Cu-catalyzed addition/cyclization cascade of o-cyanoarylacrylamide was developed. The process exhibits significant functional group tolerance, and provides an efficient and straightforward pathway for the synthesis of various phosphonylated quinoline-2,4(1H,3H)-diones.
ISSN:1477-0520
1477-0539
DOI:10.1039/c5ob00617a