Synthesis of naked amino-pyrroloindoline via direct aminocyclization of tryptamine

Synthesis of naked amino-pyrroloindoline via direct aminocyclization of tryptamine

The first direct access to unprotected amino-pyrroloindoline via aminocyclization of tryptamine and tryptophan has been described. A variety of structurally diverse amino-pyrroloindolines are furnished by the use of O-(2,4-dinitrophenyl)hydroxylamine (DPH) as the nitrogen source in the presence of c...

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Veröffentlicht in:Organic & biomolecular chemistry 2015-05, Vol.13 (19), p.5381-5384
Hauptverfasser: Shen, Zhigao, Xia, Zilei, Zhao, Huijun, Hu, Jiadong, Wan, Xiaolong, Lai, Yisheng, Zhu, Chen, Xie, Weiqing
Format: Artikel
Sprache:eng
Schlagworte:
Alkaloids - chemistry
Amines - chemical synthesis
Amines - chemistry
Cyclization
Indoles - chemical synthesis
Indoles - chemistry
Pyrroles - chemical synthesis
Pyrroles - chemistry
Tryptamines - chemical synthesis
Tryptamines - chemistry
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Zusammenfassung:The first direct access to unprotected amino-pyrroloindoline via aminocyclization of tryptamine and tryptophan has been described. A variety of structurally diverse amino-pyrroloindolines are furnished by the use of O-(2,4-dinitrophenyl)hydroxylamine (DPH) as the nitrogen source in the presence of catalytic Rh2(esp)2.
ISSN:1477-0520
1477-0539
DOI:10.1039/c5ob00546a