Participation of T cell immunoglobulin and mucin domain-3 (TIM-3) and its ligand (galectin-9) in the pathogenesis of active generalized vitiligo

Vitiligo is a depigmentary disease where melanocytes of the basal layer of epidermis are selectively destroyed by immune-cell-mediated cytotoxicity. The T cell immunoglobulin- and mucin-domain-containing molecules (TIMs) are involved in immune regulation, and their participation is not known in viti...

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Veröffentlicht in:	Immunologic research 2015-05, Vol.62 (1), p.23-34
Hauptverfasser:	Tembhre, Manoj Kumar, Parihar, Anita Singh, Sharma, Alpana, Gupta, Somesh, Chattopadhyay, Parthaprasad, Sharma, Vinod Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Allergology Autoimmune diseases Biomedical and Life Sciences Biomedicine CD3 Complex - metabolism CD4 Antigens - metabolism Cytotoxicity Female Galectins - genetics Galectins - metabolism Hepatitis A Virus Cellular Receptor 1 Hepatitis A Virus Cellular Receptor 2 Humans Immunoglobulins Immunology Immunophenotyping Interferon-gamma - genetics Interferon-gamma - metabolism Interleukin-4 - genetics Interleukin-4 - metabolism Internal Medicine Ligands Male Medicine/Public Health Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Pathogenesis Receptors, Virus - genetics Receptors, Virus - metabolism RNA, Messenger - metabolism Skin - metabolism T-Lymphocytes - metabolism Vitiligo - metabolism Young Adult
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Zusammenfassung:	Vitiligo is a depigmentary disease where melanocytes of the basal layer of epidermis are selectively destroyed by immune-cell-mediated cytotoxicity. The T cell immunoglobulin- and mucin-domain-containing molecules (TIMs) are involved in immune regulation, and their participation is not known in vitiligo. The present study revealed significant increase in the percentage of CD3+CD4+TIM3+ T cells ( P
ISSN:	0257-277X 1559-0755
DOI:	10.1007/s12026-015-8632-6