A local renin-angiotensin-like system in the heart of an African lungfish ( Protopterus annectens)

The presence of components of a renin-angiotensin system was investigated in the heart of an African lungfish Protopterus annectens. A renin-like activity is present in heart homogenates. The activity reaches its maximum after 90 min of incubation at 20°C. By a spectrophotometric assay, an angiotens...

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Veröffentlicht in:	Comparative biochemistry and physiology. A, Comparative physiology Comparative physiology, 1995, Vol.110 (3), p.229-233
Hauptverfasser:	Masini, Maria Angela, Devecchi, Monica, Napoli, Laura, Uva, Bianca Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin converting enzyme Angiotensin II Dipnoan Freshwater Heart Lungfish Protopterus annectens Renin activity Renin-angiotensin system
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Zusammenfassung:	The presence of components of a renin-angiotensin system was investigated in the heart of an African lungfish Protopterus annectens. A renin-like activity is present in heart homogenates. The activity reaches its maximum after 90 min of incubation at 20°C. By a spectrophotometric assay, an angiotensin converting enzyme-like activity was detected. By immunohistochemistry Ile 5-Angiotensin II immunoreactive cardiocytes were demonstrated in the atrium and bulbus. Our data indicate that probably a local renin-angiotensin-like system is present in the heart of Protopterus annectens.
ISSN:	0300-9629
DOI:	10.1016/0300-9629(94)00171-O