Additive effect of clarithromycin combined with 14-hydroxy clarithromycin, erythromycin, amoxycillin, metronidazole or omeprazole against Helicobacter pylori

The in-vitro activities of clarithromycin, 14-OH clarithromycin, erythromycin, amoxycillin, metronidazole and omeprazole against Helicobacter pylori were determined at pH 7.2 and 5.5. At pH 5.5 the activities of clarithromcycin and erythromycin decreased approximately 16 times while 14-OH clarithrom...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 1994-12, Vol.34 (6), p.1025-1029
Hauptverfasser:	Cederbrant, Gunilla, Kahlmeter, Gunnar, Schatén, Claes, Kamme, Carl
Format:	Artikel
Sprache:	eng
Schlagworte:	Amoxicillin - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Clarithromycin - analogs & derivatives Clarithromycin - metabolism Clarithromycin - pharmacology Drug Synergism Drug Therapy, Combination - pharmacology Erythromycin - pharmacology Helicobacter pylori Helicobacter pylori - drug effects Humans Hydrogen-Ion Concentration Medical sciences Metronidazole - pharmacology Microbial Sensitivity Tests Omeprazole - pharmacology Pharmacology. Drug treatments
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Zusammenfassung:	The in-vitro activities of clarithromycin, 14-OH clarithromycin, erythromycin, amoxycillin, metronidazole and omeprazole against Helicobacter pylori were determined at pH 7.2 and 5.5. At pH 5.5 the activities of clarithromcycin and erythromycin decreased approximately 16 times while 14-OH clarithromycin was less influenced. Chequerboard titration indicated that the combined activity of clarithromycin and the other compounds was additive.
ISSN:	0305-7453 1460-2091
DOI:	10.1093/jac/34.6.1025