Improvement in detection limits for the determination of paralytic shellfish poisoning toxins in shellfish tissues using capillary electrophoresis/electrospray mass spectrometry and discontinuous buffer systems

The application of on-column sample preconcentration with capillary isotachophoresis (CITP) and discontinuous buffer systems prior to CZE separation has been investigated for the analysis of paralytic shellfish poisoning toxins. The ease of operation, flexibility, selectivity and short analysis time of CITP/CZE/ESMS make this technique an attractive method for the monitoring of PSP toxins.