Novel 10-fraction breast irradiation in prone and supine position: technical, dosimetric and clinical evaluation

The aim of this study was to evaluate retrospectively the planned dose distribution and acute toxicity of adjuvant hypofractionated whole breast radiotherapy (RT) delivered in the prone vs. supine position. Twenty-four patients were enrolled; 12 underwent adjuvant RT with a supine setup and 12 with...

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Veröffentlicht in:Tumori 2015-03, Vol.101 (2), p.154-160
Hauptverfasser: Guenzi, Marina, Bosetti, Davide, Lamanna, Giorgio, Siffredi, Guido, Bonzano, Elisabetta, Gusinu, Marco, Garelli, Stefania, Pupillo, Francesco, Corvò, Renzo
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container_issue 2
container_start_page 154
container_title Tumori
container_volume 101
creator Guenzi, Marina
Bosetti, Davide
Lamanna, Giorgio
Siffredi, Guido
Bonzano, Elisabetta
Gusinu, Marco
Garelli, Stefania
Pupillo, Francesco
Corvò, Renzo
description The aim of this study was to evaluate retrospectively the planned dose distribution and acute toxicity of adjuvant hypofractionated whole breast radiotherapy (RT) delivered in the prone vs. supine position. Twenty-four patients were enrolled; 12 underwent adjuvant RT with a supine setup and 12 with a prone setup. We included patients according to breast volume (≥500 mL), disease stage (≤pT2/pN1), and clinical/biological features. Patients received a regimen of 35 Gy in 10 fractions for 2.5 weeks, and a concomitant boost of 3/4 Gy in 1 fraction/week. Target coverage was assessed by volume, V90, V95, V100, V103 and V105. Heart, LADCA and ipsilateral lung doses were evaluated according to volume, maximum dose, mean dose, V14, V10 and V5. We evaluated acute skin toxicity during RT, at the end of treatment, and after 1 month according to RTOG scales. Radiobiological equivalence was warranted with satisfactory BED values: considering α/β = 4 for breast cancer, the 10-fraction schedule equaled 74 or 77 Gy depending on the boost dose (3 Gy vs. 4 Gy, respectively). Toxicity was low and similar for supine and prone treatments. Dose sparing was significant in the ipsilateral lung in the prone position (median Dmax: 28.7 Gy vs. 38.4 Gy; median Dmean: 0.8 Gy vs. 6.3 Gy; median V14: 0.6% vs. 13.5%; median V5: 0 vs. 19.3%, p
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ispartof Tumori, 2015-03, Vol.101 (2), p.154-160
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source SAGE Complete A-Z List; MEDLINE
subjects Aged
Aged, 80 and over
Breast Neoplasms - pathology
Breast Neoplasms - radiotherapy
Dose Fractionation
Dose-Response Relationship, Radiation
Erythema - etiology
Feasibility Studies
Female
Fibrosis - etiology
Humans
Lung - pathology
Lung - radiation effects
Mastectomy, Segmental
Neoplasm Staging
Organs at Risk
Prone Position
Radiometry
Radiotherapy, Adjuvant - adverse effects
Radiotherapy, Adjuvant - methods
Retrospective Studies
Skin - pathology
Skin - radiation effects
Supine Position
Treatment Outcome
title Novel 10-fraction breast irradiation in prone and supine position: technical, dosimetric and clinical evaluation
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