A comparative study of effect of oral chronic cyanide administration on some rabbit tissue ATPases

The effect of oral KCN administration on Na +-K +-ATPase, Ca 2+-ATPase and Mg 2+-ATPase activities was studied in some rabbit tissues. Generally, the order of activity of the enzymes was kidney > liver > ileum > colon. There were significant decreases ( P < 0.05) in the activities of all...

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Veröffentlicht in:	Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Comparative pharmacology and toxicology, 1994-10, Vol.109 (2), p.215-217
Hauptverfasser:	Okolie, Ngozi P., Onoagbe, Iyere O., Aisien, Felix A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals ATPase Ca(2+) Mg(2+)-ATPase - antagonists & inhibitors Calcium-Transporting ATPases - antagonists & inhibitors Cyanide Kidney - enzymology Liver - enzymology Male Potassium Cyanide - administration & dosage Potassium Cyanide - toxicity Rabbit Rabbits Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors
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Zusammenfassung:	The effect of oral KCN administration on Na +-K +-ATPase, Ca 2+-ATPase and Mg 2+-ATPase activities was studied in some rabbit tissues. Generally, the order of activity of the enzymes was kidney > liver > ileum > colon. There were significant decreases ( P < 0.05) in the activities of all the ATPases in the tissues of KCN-treated rabbits relative to controls. The decreases in Na +-K +-ATPase and Ca 2+-ATPase activities were most pronounced in liver and kidney. The decreases in ATPases suggest impairment of membrane function as a result of the toxic effect of cyanide.
ISSN:	0742-8413 1367-8280
DOI:	10.1016/0742-8413(94)00027-8