Utility of Gene Rearrangements in Lymphoid Malignancies

Molecular genetic study of lymphoid neoplasms by Southern blotting or polymerase chain reaction permits the ready detection of gene rearrangements. Clonal rearrangements of immunoglobulin and T-cell receptor genes identify neoplasms of B- and T-cell lineage, respectively. Additionally, lymphoma-spec...

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Veröffentlicht in:	Annual review of medicine 1993, Vol.44 (1), p.75-84
1. Verfasser:	Aisenberg, A C
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Gene Rearrangement, B-Lymphocyte Gene Rearrangement, T-Lymphocyte Hematologic and hematopoietic diseases Humans Leukemia, B-Cell - genetics Leukemia, T-Cell - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, B-Cell - genetics Lymphoma, T-Cell - genetics Medical sciences Oncogenes - genetics Receptors, Antigen, B-Cell - genetics Receptors, Antigen, T-Cell - genetics
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Zusammenfassung:	Molecular genetic study of lymphoid neoplasms by Southern blotting or polymerase chain reaction permits the ready detection of gene rearrangements. Clonal rearrangements of immunoglobulin and T-cell receptor genes identify neoplasms of B- and T-cell lineage, respectively. Additionally, lymphoma-specific chromosome translocations involving oncogenes are detected with the same molecular techniques. Probes are currently available to study the c-myc translocations of Burkitt's lymphoma, the bcl-2 translocations of follicular lymphomas, and the bcl-1 translocations of centrocytic lymphoma.
ISSN:	0066-4219 1545-326X
DOI:	10.1146/annurev.me.44.020193.000451